Host: Dane Cook, Musical Guest The Killers
Host: Jaime Pressly, Musical Guest: Corinne Bailey Rae
Host: John C. Reilly, Musical Guest: My Chemical Romance
Host: Hugh Laurie, Musical Guest: Beck
Host: Alec Baldwin, Musical guest: Christina Aguilera
Host and musical guest: Ludacris
Host: Matthew Fox, Musical guest: Tenacious D
Host: Annette Bening, Musical guest: Gwen Stefani, Akon
Host and musical guest: Justin Timberlake
Host: Jake Gyllenhaal, Musical guest: The Shins
Host: Jeremy Piven, Musical guest: AFI
Host: Drew Barrymore, Musical guest: Lily Allen
Host: Forest Whitaker, Musical guest: Keith Urban
Host: Rainn Wilson, Musical guest: Arcade Fire
Host: Julia Louis-Dreyfus, Musical guest: Snow Patrol
Host: Peyton Manning, Musical guest: Carrie Underwood
Host: Shia LaBeouf, Musical guest: Avril Lavigne
Host: Scarlett Johansson, Musical guest: Björk
Host: Molly Shannon, Musical guest: Linkin Park
Host: Zach Braff, Musical guest: Maroon 5
